Dog Supplement Ingredients Research

Ingredient Name Health Area Research Source
Amylase Gastro Dr. Heinze, C. (2017, October 30). Digestive Enzyme Supplements: Breaking Down the Evidence. Read more
Beta-Glucan Immune
1) Ferreira LGEndrighi MLisenko KG, et al. PubMed (2018, July 31). Oat beta-glucan as a dietary supplement for dogs. Read more
2) Stephenson, K. Preventing Disease: Beta Glucan, Mushrooms And Dogs. Read more
Bifidobacterium Bifidum Gastro & Immune

PubMed (2009 Fall). "Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea." Read more

Bromelain Immune Biotechnology Research International (2012, Dec 10). Read more
Carnitine Heart

Dr. Coates, J. (2012, June 8). When Taurine and Carnitine Supplements Are a Good Idea. Read more

Cellulase Gastro

Dr. Heinze, C. (2017, October 30). Digestive Enzyme Supplements: Breaking Down the Evidence. Read more

Chitosan Kidney

Jing SB, et al. (2011, April 12). Effect of Chitosan on Renal Function in Patients with Chronic Renal Failure. Journal of Pharmacy and Pharmacology. Read more

Chondroitin Sulfate Joints & Muscles

1) Bhathal, A.,  Spryszak, M., Louizos, C., and Frankel, G. (2017, Feb 24). Glucosamine and chondroitin use in canines for osteoarthritis: A review. Open Vetirinary Journal.  Read more

2) Nganvongpanit, K., Itthiarbha, A., Ong-Chai, S., Kongtawelert, P., (2008, Sept 30). Evaluation of serum chondroitin sulfate and hyaluronan: biomarkers for osteoarthritis in canine hip dysplasia. Read more

Colostrum Immune

Hurley, W., Thiel, P. (2011, Apr). Perspectives on Immunoglobulins in Colostrum and Milk. Nutrients. Read more 

Cranadinin (Cranberry extract) Kidneys

Walden, L. A., (2017, Jan 9). Effect of Cranberry Extract on Bacteriuria in Dogs with Intervertebral Disk Herniation. American Veterinarian. Read more

Curcumin Gastro Levine, C.B., Bayle, J., Biourge, V., Wakshlag, J.J. (2017, Dec 13). Cellular effects of a turmeric root and rosemary leaf extract on canine neoplastic cell lines. BMC Veterinary Research. Read more
Digestive Enzymes Gastro 1) Villaverde, C., Manzanilla, EG., Molina, J., Larsen, JA. (2017 Apr 18). Effect of enzyme supplements on macronutrient digestibility by healthy adult dogs. Journal of Nutritional Science. Read more
2) Heinze, C., (2017 Oct 30). Digestive Enzyme Supplements: Breaking Down the Evidence. Cummins Veterinary Medical Center at Tufts University. Read more
Enterococcus spp Gastro & Immune Kubasova, I., Strompfova, V., Laukova, A. (2017 Nov). Safety assessment of commensal enterococci from dogs. Folia Micobiologica. Read more
Essential Amino Acids Overall health Stephens, J.R., Woolson, R.F., Cooke A.R. (1975 Oct). Effects of essential and nonessential amino acids on gastric emptying in the dog. Gastroenterology. Read more
Garlic Tablets Immune
Folate (Folic Acid) Immune Henry, C.J.Nemkov, T.Casás-Selves, M.Bilousova, GZaberezhnyy, V.Higa, K.C.Serkova, N.J.Hansen, K.C.D'Alessandro, A.DeGregori, J. (2017, Dec). Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis. Haematologica. Read more
Glucosamine Joints & Bones

Bhathal, A., Spryszak, M., Louizos, C., Frankel, G. (2017). Glucosamine and chondroitin use in canines for osteoarthritis. Open Veterinary Journal. Read more

Green Lipped Mussels Joints & Bones

Heilm-Bjorkman, A., Tulamo R-M., Salonen, H., Raekallio, M. (2007, oct 29). Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel. Evidence-Based Complementary and Alternative Medicine. Read more

Hawthorn Heart

Alp, H., Soner, B. C., Baysal, T., Sahin, A. S. (2016, Dec). Protective effects of Hawthorn (Crataegus oxyacantha) extract against digoxin-induced arrhythmias in rats. The Anatolian Journal of Cardiology. Read more

Hyaluronic Acid Joints

Nganvongpanit, K., Boonsri, B., Spipratak, T., Markmee, P. (2013 Jun 21). Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs. Journal of Veterinary Science. Read more

Kaolin-Pectin Gastro 1) Nixon, S., Rose, L., Muller, A. (2019, Mar 18) Efficacy of an orally administered anti-diarrheal probiotic paste in dogs with acute diarrhea. Jounral of Vetirinary Internal Medicine. Read more
2) Marks, S. (2013). Canine and Feline Gastroenterology. Read more
Kelp Immune

Dodds, W. J. (2014, Jul 5). Is Kelp the Cure-All For Canine Thyroid Conditions? Hemopet. Read more

L-Carnitine Heart 1) Saderson, S.L. (2006, Nov). Taurine and carnitine in canine cardiomyopathy. Veterinary Clinics of North America: Small Animal Practice. Read more
2) Neumann, S., Welling, H., Thuere, S., Kaup F.J. (2007, Jun). Plasma L-carnitine concentration in healthy dogs and dogs with hepatopathy. Veterinary Clinical Pathology. Read more
L-Glutamine Gastro
1) Hung, C.R., Takeuchi, K., Okabe. S., Murata, T., Takagi, K. (1976, Dec). Effects of L-glutamine on acetylsalycylic acid induced gastric lesions and acid back diffusion in dogs. The Japanese Journal of Pharmacology. Read more
2) Jiang, Z.M., Wang, L.J., Qi, Y., Liu, T.H., Qiu, M.R., Yang, N.F., Wilmore, D.W. (1993, Mar). Comparison of parenteral nutrition supplemented with L-glutamine or glutamine dipeptides. The Journal of Parenteral and Enteral Nutrition. Read more
Lactalbumin Immune Whipple, G.H., Robscheit-Robbins, F.S. (1951, Sep). Anemia Plus Hypoproteinemia in Dogs. Journal of Experimental Medicine. Read more
Lactobacillus spp Gastro & Immune 1) Pere-Vedrenne, C., Flanou, B., Loke, M.F., Menard, A., Vadivelu, J. (2017, Sep). Other Helicobacters, gastric and gut microbiota. Helicobacter. Read more
2) Baillon, M.L., Marshall-Jones, Z.V., Butterwick, R.F. (2004, Mar). Effects of probiotic Lactobacillus acidophilus strain DSM13241 in healthy adult dogs. Read more
3) Pascher, M.Hellweg, P.Khol-Parisini, A.Zentek, J. (2008, Apr). Effects of a probiotic Lactobacillus acidophilus strain on feed tolerance in dogs with non-specific dietary sensitivity. Archives of Animal Nutrition. Read more
Lipase Gastro Villaverde, C., et al. (2017). Effect of enzyme supplements on macronutrient digestibility by healthy adult dogs. Journal of Nutritional Science. Read more
Mannan oligosaccharides Gastro Pawar, M.M., Pattanaik, A. K., Sinha, D.K., Goswami, T.K., Sharma K. (2017, May). Effect of dietary mannanoligosaccharide supplementation on nutrient digestibility, hindgut fermentation, immune response and antioxidant indices in dogs. Journal of Animal Science and Technology. Read more
Melatonin Cognitive, Stress 1) Niggermann, J.R., Eberspacher-Schweda, M.C., Eberspacher-Schweda, E. (2019. Sep). Preoperative calming effect of melatonin and its influence on propofol dose for anesthesia induction in healthy dogs. Veterinary Anaesthesia and Analgesia. Read more
2) May, K. A., Laflamme, D. (2019. Dec). Nutrition and the Aging Brain of Dogs and Cats. Journal of the American Veterinary Medical Association. Read more
Methylsulfonylmethane (MSM) Joints & Bones 1) Butawan, M., Benjamin, R. L., Bloomer, R. J. (2017 Mar). Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients Journal. Read more
2) Aljohani, H.Senbanjo, L.T.Chellaiah, M.A. (2019 Dec). Methylsulfonylmethane increases osteogenesis and regulates the mineralization of the matrix by transglutaminase 2 in SHED cells. PLOS One. Read more
Olive leaf extract Immune Wong, C., Fogoros, R. (2019, Oct). The Health Benefits of Olive Leaf Extract. Verywell Health. Read more
Omega 3 fatty acids Skin & Immune 1) Matinez, N., McDonald, B., Martinez-Taboada, F. (2019, Nov 5). Exploring the use of essential fatty acids in veterinary dermatology. Veterinary Record. Read more
2) Huhmann, R., Mueller, R.S. (2019, Apr). A cream containing omega-3-fatty acids, humectants and emollients as an aid in the treatment of equine Culicoides hypersensitivity. Vetirinary Dermatology. Read more
3) Zeiner, M.L., Nodtvedt, A. (2014, Oct). A treatment study of canine symmetrical onychomadesis (symmetrical lupoid onychodystrophy) comparing fish oil and cyclosporine supplementation in addition to a diet rich in omega-3 fatty acids. Acta Veterinaria Scandinavica. Read more
Pectin Gastro Nixon, S.L., Rose, L., Muller, A.T. (2019, May). Efficacy of an orally administered anti-diarrheal probiotic paste (Pro-Kolin Advanced) in dogs with acute diarrhea: A randomized, placebo-controlled, double-blinded clinical study. Journal of Veterinary Internal Medicine. Read more
Primerose Oil Skin & Coat 1) Scardd, D.H., Lloyd, D.H. (1992 Aug). Double blind, placebo-controlled, crossover study of evening primrose oil in the treatment of canine atopy. Vetirinary Record. Read more
2) Sture, G.H., Lloyd, D.H. (1995 Aug). Canine atopic disease: therapeutic use of an evening primrose oil and fish oil combination. Vetirinary Record. Read more
3) Bond R., Lloyd, D.H. (1994, Jan 8). Combined treatment with concentrated essential fatty acids and prednisolone in the management of canine atopy. Vetirinary Record. Read more
Proline Rich Polypeptides Immune Wang, H., Ji, F., Liang, H., Gu, H. Nigh, Z., Liu, R., Zhang, G. (2015 Jul 15). A Proline-Rich Domain in the Genotype 4 Hepatitis E Virus ORF3 C-Terminus Is Crucial for Downstream V105DLP108 Immunoactivity. PLOS One. Read more
Protease Gastro Muñoz-Prieto, A.Martínez-Subiela, S.Caldin, M.Cerón, J.J.Tvarijonaviciute, A. (2019 Jul). Use of proteases for the evaluation of the different adiponectin isoforms in the dog. Domestic Animal Endocrinology. Read more
Psyllium Husk Gastro Deng, P., Beloshapka, A.N., Vester Boler, B.M., Swanson, K.S. (2013, Sep 14). Dietary fibre fermentability but not viscosity elicited the 'second-meal effect' in healthy adult dogs. British Journal of Nutrition. Read more
Q10 Heart Svete, A.N.Verk, B.Seliškar, A.Tomsič, K.Križman, P.J.Petrič, A.D. (2017 Apr). Plasma coenzyme Q10 concentration, antioxidant status, and serum N-terminal pro-brain natriuretic peptide concentration in dogs with various cardiovascular diseases and the effect of cardiac treatment on measured variables. American Journal of Veterinary Research. Read more
Quercetin Immune Xiao, Y.Xin, L.Li, L.Li, G.Shi, X.Ji, G.Mi, J.Xie, Y. (2019 Feb). Quercetin and kaempferol increase the intestinal absorption of isorhamnetin coexisting in Elaeagnus rhamnoides (L.) A. Nelson (Elaeagnaceae) extracts via regulating multidrug resistance-associated protein 2. Phytomedicine Journal. Read more
Resveratrol Immune 1) Mathew, L.M.Woode, R.A.Axiak-Bechtel, S.M.Amorim, J.R.DeClue, A.E. (2018 Sep). Resveratrol administration increases phagocytosis, decreases oxidative burst, and promotes pro-inflammatory cytokine production in healthy dogs. Veterinary Immunology and Immunopathology. Read more
2) Zhao, X.E.Yang, Z.Zhang, H.Yao, G.Liu, J.Wei, Q.Ma, B. (2018 Dec). Resveratrol Promotes Osteogenic Differentiation of Canine Bone Marrow Mesenchymal Stem Cells Through Wnt/Beta-Catenin Signaling Pathway. Cellular Reprogramming. Read more
S-adenosyl I-methionine Joints & Bones 1) Imhoff, D.J.Gordon-Evans, W.J.Evans, R.B.Johnson, A.L.Griffon, D.J.Swanson, K.S. (2011 Feb). Evaluation of S-adenosyl l-methionine in a double-blinded, randomized, placebo-controlled, clinical trial for treatment of presumptive osteoarthritis in the dog. Veterinary Surgery Journal. Read more
2) Wallace, K.P.Center, S.A.Hickford, F.H.Warner, K.L.Smith, S. (2002 May). S-adenosyl-L-methionine (SAMe) for the treatment of acetaminophen toxicity in a dog. Journal of the American Animal Hospital Association. Read more
Sacchromyces Boulardii Gastro D'Angelo, S.Fracassi, F.Bresciani, F.Galuppi, R.Diana, A.Linta, N.Bettini, G.Morini, M.Pietra, M. (2018 Mar). Effect of Saccharomyces boulardii in dog with chronic enteropathies: double-blinded, placebo-controlled study. Vet Record. Read more
Silymarin Kidney 1) Liu, Z.H.Li, X.J.Huang, A.W.Zhang, J.Song, H.T. (2017 May). Preparation and Characterization of Silymarin Synchronized and Sustained Release Dropping Pill. Current Drug Delivery. Read more
2) Varzi,H.N.Esmailzadeh, S.Morovvati,H.Avizeh, R.Shahriari, A.Givi, M.E. (2007 Oct). Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs. The Journal of Vetirinary Pharmacology and Therapeutics. Read more
Spirulina Immune Chen, Y.H.Chang, G.K.Kuo, S.M.Huang, S.Y.Hu, I.C.Lo, Y.L.Shih, S.R. 2016 Apr). Well-tolerated Spirulina extract inhibits influenza virus replication and reduces virus-induced mortality. Scientific Reports. Read more
Taurine Heart

Kaplan, J.L.Stern, J.A.Fascetti, A.J.Larsen, J.A.Skolnik, H.Peddle, G.D., et al. (2018 Dec). Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets. PLOS One. Read more

Turkey Tail Mushroom Powder Immune Sean, R. (2018 Jan). Top 5 Best Mushrooms for Fighting Cancer in Dogs: Turkey Tail, Reishi, Chaga, Cordyceps, and Lion’s Mane. Doggie Herbs. Read more